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As granulomas mature, they develop fibrous walls and experience a significant decrease in the number of vessels penetrating the structure, which hampers the penetration of anti-TB drugs into the necrotic and hypoxic areas of the granuloma, where M.tb persists [98, 99]

If left untreated, pancreatitis can lead to life-threatening complications, including permanent damage to the pancreas

injections of 10 nmol kg 1 semaglutide ( n = 6 mice and n = 3 cages), 100 nmol kg 1 GLP-1MK-801 ( n = 6 mice and n = 3 cages) or vehicle (isotonic saline, n = 6 mice and n = 3 cages) for 5 days